Rohde PD, Madsen LS, Neumann Arvidson SM, Loeschcke V, Demontis D, Kristensen TN. Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior. Fly (Austin). 2016 Jan 2;10(1):25-34. PMID: 26954609; PMCID: PMC4934711.
From the abstract: "... Here we use a high-throughput locomotor activity assay to test the response on activity behavior of gene disruption in Drosophila melanogaster. The aim was to investigate the impact of disruption of 14 candidate genes for human attention-deficit/hyperactivity disorder (ADHD) on fly behavior. By obtaining a range of correlated measures describing the space of variables for behavioral activity we show, that some mutants display similar phenotypic responses, and furthermore, that the genes disrupted in those mutants had common molecular functions; namely processes related to cGMP activity, cation channels and serotonin receptors. ... Results provide additional support for the investigated genes being risk candidate genes for ADHD in humans."
Showing posts with label Attention Deficit Hyperactivity Disorder. Show all posts
Showing posts with label Attention Deficit Hyperactivity Disorder. Show all posts
Monday, August 14, 2017
Monday, February 15, 2016
Fly study suggests link between bisphenol A (BPA), found in some plastics, and ADHD and autism
The results suggest BPA is a risk factor for the behavioral impairments that are the basis of autism and ADHD https://t.co/xzhUxws8ql
— Thomas Brody (@interactivefly) February 15, 2016
Wednesday, January 13, 2016
Report of a fly model of ADHD
Zhang Q, Du G, John V, Kapahi P, Bredesen DE. Alzheimer's Model Develops Early ADHD Syndrome. J Neurol Neurophysiol. 2015;6(6):1-6. PMID: 26753104.
From the abstract: "We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, ... This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms."
From the abstract: "We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, ... This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms."
Wednesday, May 13, 2015
'Locomotor signature' suggests fly model can be useful for ADHD-related studies
van der Voet M, Harich B, Franke B, Schenck A. ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila. Mol Psychiatry. 2015 May 12. doi: 10.1038/mp.2015.55. PMID: 25962619.
From the abstract: "Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder with hyperactivity as one of the hallmarks. ... Here we report a Drosophila dopamine-related locomotor endophenotype that is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity: Neurofibromin (NF1). The locomotor signature was not found in control models and could be ameliorated by methylphenidate, validating its relevance to symptoms of the disorder. The Drosophila ADHD endophenotype can be further exploited in high throughput to characterize the growing number of candidate genes. ..."
From the abstract: "Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder with hyperactivity as one of the hallmarks. ... Here we report a Drosophila dopamine-related locomotor endophenotype that is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity: Neurofibromin (NF1). The locomotor signature was not found in control models and could be ameliorated by methylphenidate, validating its relevance to symptoms of the disorder. The Drosophila ADHD endophenotype can be further exploited in high throughput to characterize the growing number of candidate genes. ..."
Monday, November 4, 2013
Fly assay helps confirm relevance of ANK3 disruptions to neurodevelopmental disorders. Recent report.
Iqbal Z, Vandeweyer G, van der Voet M, Waryah AM, Zahoor MY, Besseling JA, Roca LT, Vulto-van Silfhout AT, Nijhof B, Kramer JM, Van der Aa N, Ansar M, Peeters H, Helsmoortel C, Gilissen C, Vissers LE, Veltman JA, de Brouwer AP, Frank Kooy R, Riazuddin S, Schenck A, van Bokhoven H, Rooms L. Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders. Hum Mol Genet. 2013 May 15;22(10):1960-70. PMID: 23390136.
From the abstract: "... The causality of ANK3 mutations in the two families and the role of the gene in cognitive function were supported by memory defects in a Drosophila knockdown model. ...
From the abstract: "... The causality of ANK3 mutations in the two families and the role of the gene in cognitive function were supported by memory defects in a Drosophila knockdown model. ...
Wednesday, September 19, 2012
Drosophila as a model for lead toxicity. Recent report.
Hirsch HV, Lnenicka G, Possidente D, Possidente B, Garfinkel MD, Wang L, Lu X, Ruden DM. Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research. Front Genet. 2012;3:68. PubMed PMID: 22586431; PubMed Central PMCID: PMC3343274.
The authors point out that parallels between the effects of lead poisoning and disorders such as attention deficit hyperactivity disorder (ADHD) suggest that studying lead neurotoxicology might have impact in additional fields of study.
The authors point out that parallels between the effects of lead poisoning and disorders such as attention deficit hyperactivity disorder (ADHD) suggest that studying lead neurotoxicology might have impact in additional fields of study.
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