Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS Genet. 2019 Aug 15;15(8):e1008318. PubMed PMID: 31415568; PubMed Central PMCID: PMC6695094.
From the abstract: "Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. ... In humans, elevated UA levels resulted from the loss of the of the urate oxidase (Uro) gene ... we established a Drosophila melanogaster model with reduced expression of the orthologous Uro gene to study the pathogenesis arising from elevated UA. Reduced Uro expression in Drosophila resulted in elevated UA levels, accumulation of concretions in the excretory system, and shortening of lifespan ..."
Showing posts with label Diabetic nephropathy. Show all posts
Showing posts with label Diabetic nephropathy. Show all posts
Monday, September 30, 2019
Tuesday, August 28, 2018
Drosophila, diabetes, and kidney disease
Rani L, Gautam NK. Drosophila renal system as an in-vivo tool for target identification and screening of potential therapeutics for the diabetic nephropathy. Curr Drug Targets. 2018 Aug 7. PMID: 30088447.
From the abstract: "... This review provides evidence for the use of Drosophila renal system as an in-vivo tool for identifying drug target against the disease. ... It also illustrates the use of Drosophila based tools for pre-screening of a potential drug for the disease."
From the abstract: "... This review provides evidence for the use of Drosophila renal system as an in-vivo tool for identifying drug target against the disease. ... It also illustrates the use of Drosophila based tools for pre-screening of a potential drug for the disease."
Thursday, August 20, 2015
Flies, podocytes and diabetic nephropathy
Na J, Sweetwyne MT, Park AS, Susztak K, Cagan RL. Diet-Induced Podocyte Dysfunction in Drosophila and Mammals. Cell Rep. 2015 Jul 28;12(4):636-47. PMID: 26190114; PMCID: PMC4532696.
From the abstract: "Diabetic nephropathy is a major cause of end-stage kidney disease. Characterized by progressive microvascular disease, most efforts have focused on injury to the glomerular endothelium. Recent work has suggested a role for the podocyte, a highly specialized component of the glomerular filtration barrier. Here, we demonstrate that the Drosophila nephrocyte, a cell analogous to the mammalian podocyte, displays defects that phenocopy aspects of diabetic nephropathy in animals fed chronic high dietary sucrose. Through functional studies, we identify an OGT-Polycomb-Knot-Sns pathway that links dietary sucrose to loss of the Nephrin ortholog Sns ..."
From the abstract: "Diabetic nephropathy is a major cause of end-stage kidney disease. Characterized by progressive microvascular disease, most efforts have focused on injury to the glomerular endothelium. Recent work has suggested a role for the podocyte, a highly specialized component of the glomerular filtration barrier. Here, we demonstrate that the Drosophila nephrocyte, a cell analogous to the mammalian podocyte, displays defects that phenocopy aspects of diabetic nephropathy in animals fed chronic high dietary sucrose. Through functional studies, we identify an OGT-Polycomb-Knot-Sns pathway that links dietary sucrose to loss of the Nephrin ortholog Sns ..."
Tuesday, July 21, 2015
New study in flies and mammals related to diabetic nephropathy
Diet-Induced Podocyte Dysfunction in Drosophila and Mammals. http://t.co/JJpcdLzpRA
— flypapers (@fly_papers) July 21, 2015
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