Prakash Bokolia N, Mishra M. Hearing molecules, mechanism and transportation: Modeled in Drosophila melanogaster. Dev Neurobiol. 2014 Aug 1. PMID: 25081222.
From the abstract: "... The current review describes the similarities and differences between the vertebrate and fly auditory organs at developmental, structural, molecular and transportation levels."
Showing posts with label Deafness. Show all posts
Showing posts with label Deafness. Show all posts
Tuesday, August 5, 2014
Tuesday, April 8, 2014
Fly and human studies related to Wolfram syndrome
Jones MA, Amr S, Ferebee A, Huynh P, Rosenfeld JA, Miles MF, Davies AG, Korey CA, Warrick JM, Shiang R, Elsea SH, Girirajan S, Grotewiel M. Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease. Biol Open. 2014 Apr 4. pii: bio.20147559v1. PMID: 24705017.
Friday, August 31, 2012
Drosophila models of deafness. Foundational report.
This paper describes a large-scale effort to further develop Drosophila as a model for study of hearing and hearing-related diseases.
Pingkalai R. Senthilan, David Piepenbrock, Guvanch Ovezmyradov, Björn Nadrowski, Susanne Bechstedt, Stephanie Pauls, Margret Winkler, Wiebke Möbius, Jonathon Howard, Martin C. Göpfert. Drosophila Auditory Organ Genes and Genetic Hearing Defects. Cell 31 August 2012 (Vol. 150, Issue 5, pp. 1042-1054).
The study includes but is not limited to comparative mRNA analysis to identify relevant transcripts; in situ hybridization to visualize transcripts in a relevant organ; and characterization of auditory phenotypes. A Cell 'Preview' article by Lewis & Steel is also available. These authors describe the study by Senthilan et al. as providing "a new resource to aid identification of genes involved in deafness."
Pingkalai R. Senthilan, David Piepenbrock, Guvanch Ovezmyradov, Björn Nadrowski, Susanne Bechstedt, Stephanie Pauls, Margret Winkler, Wiebke Möbius, Jonathon Howard, Martin C. Göpfert. Drosophila Auditory Organ Genes and Genetic Hearing Defects. Cell 31 August 2012 (Vol. 150, Issue 5, pp. 1042-1054).
The study includes but is not limited to comparative mRNA analysis to identify relevant transcripts; in situ hybridization to visualize transcripts in a relevant organ; and characterization of auditory phenotypes. A Cell 'Preview' article by Lewis & Steel is also available. These authors describe the study by Senthilan et al. as providing "a new resource to aid identification of genes involved in deafness."
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