Loss of SMN1 activity leads to Spinal Muscular Atrophy (SMA). In this study, the fly ortholog of SMN1 was knocked down by RNAi in neurons and muscles.
Timmerman C, Sanyal S. Behavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster. Brain Res. 2012 Oct 25. doi:pii: S0006-8993(12)01692-7. 10.1016/j.brainres.2012.10.035. PubMed PMID: 23103409.
Showing posts with label Spinal and Bulbar Muscular Atrophy. Show all posts
Showing posts with label Spinal and Bulbar Muscular Atrophy. Show all posts
Friday, November 2, 2012
Tuesday, October 16, 2012
Fly model of SMA. SMN in Neural Network Activity. Recent Report.
Imlach WL, Beck ES, Choi BJ, Lotti F, Pellizzoni L, McCabe BD. SMN Is Required for Sensory-Motor Circuit Function in Drosophila. Cell. 2012 Oct 12;151(2):427-39. doi: 10.1016/j.cell.2012.09.011. PubMed PMID: 23063130.
Friday, September 28, 2012
SMBA & Poly-Q study. Recent report.
Jochum T, Ritz ME, Schuster C, Funderburk SF, Jehle K, Schmitz K, Brinkmann F, Hirtz M, Moss D, Cato AC. Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures. Biochim Biophys Acta. 2012 Jun;1822(6):1070-8. PubMed PMID: 22366762.
The authors indicate that they used two existing fly stocks, pUAST-ARQ22 and pUAST-ARQ22dm, and generated two new transgenic stocks, pUAST-ARQ1 and -ARQ65, for the study. These are pathogenic forms of the human androgen receptor protein. See this FlyBase page for more info on human AR transgenic flies. To induce expression of the AR forms, these authors used the OK371-GAL4 driver fly stock.
The authors indicate that they used two existing fly stocks, pUAST-ARQ22 and pUAST-ARQ22dm, and generated two new transgenic stocks, pUAST-ARQ1 and -ARQ65, for the study. These are pathogenic forms of the human androgen receptor protein. See this FlyBase page for more info on human AR transgenic flies. To induce expression of the AR forms, these authors used the OK371-GAL4 driver fly stock.
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