Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN; NIH ARRA Autism Sequencing Consortium, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Mol Psychiatry. 2013 Dec;18(12):1315-1323. PMID: 23979605.
From the abstract: "De novo genetic variation is an important class of risk factors for autism spectrum disorder (ASD). Recently, whole-exome sequencing of ASD families has identified a novel de novo missense mutation in the human dopamine (DA) transporter (hDAT) gene, which results in a Thr to Met substitution at site 356 (hDAT T356M). ... In Drosophila melanogaster, the expression of hDAT T356M in DA neurons-lacking Drosophila DAT leads to hyperlocomotion, a trait associated with DA dysfunction and ASD."
Accompanying image: Hamilton PJ, Campbell NG, Sharma S, Erreger K, Hansen FH, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene. Mol Psychiatry. 2013 Dec;18(12):1235. PMID: 24253181
Friday, November 22, 2013
Polarity gene Crumbs & A-beta-42-mediated neurodegeneration. Alzhemier's Disease-related fly study.
Steffensmeier AM, Tare M, Puli OR, Modi R, Nainaparampil J, Kango-Singh M, Singh A. Novel Neuroprotective Function of Apical-Basal Polarity Gene Crumbs in Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration. PLoS One. 2013 Nov 18;8(11):e78717. PMID: 24260128.
Wednesday, November 20, 2013
Light treatment and fly Parkinson's Disease model.
Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H, Ginggen A, De Strooper B, Tardy Y, Verstreken P. Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model. PLoS One. PMID: 24244323.
From the abstract: "Irradiating Drosophila pink1 mutants using a single dose of 808 nm light results in a rescue of major systemic and mitochondrial defects."
From the abstract: "Irradiating Drosophila pink1 mutants using a single dose of 808 nm light results in a rescue of major systemic and mitochondrial defects."
Mammalian Parkin protein interaction study uses fly data in assigning confidence.
Zanon A, Rakovic A, Blankenburg H, Doncheva NT, Schwienbacher C, Serafin A, Alexa A, Weichenberger CX, Albrecht M, Klein C, Hicks AA, Pramstaller PP, Domingues FS, Pichler I. Profiling of parkin-binding partners using tandem affinity purification. PLoS One. 2013 PMID: 24244333.
Honing in on specific cells involved in locomotion. Parkinson's Disease-related fly study.
Riemensperger T, Issa AR, Pech U, Coulom H, Nguyễn MV, Cassar M, Jacquet M, Fiala A, Birman S. A Single Dopamine Pathway Underlies Progressive Locomotor Deficits in a Drosophila Model of Parkinson Disease. Cell Rep. 2013 Nov 13. PMID: 24239353.
Wednesday, November 13, 2013
Bisphenol A & obesity.
Williams MJ, Wang Y, Klockars A, Lind PM, Fredriksson R, Schiöth HB. Exposure to Bisphenol A (BPA) Affects Lipid Metabolism in Drosophila melanogaster. Basic Clin Pharmacol Toxicol. 2013 Nov 11. doi: 10.1111/bcpt.12170. PMID: 24215246.
From the abstract: "Exposure to bisphenol A (BPA) in rodents was shown to induce obesity ... We employed the genetically tractable model organism, Drosophila melanogaster, to test the effects of raising them on food containing various concentrations of BPA. ... we conclude that BPA may inhibit lipid recruitment during starvation in Drosophila."
From the abstract: "Exposure to bisphenol A (BPA) in rodents was shown to induce obesity ... We employed the genetically tractable model organism, Drosophila melanogaster, to test the effects of raising them on food containing various concentrations of BPA. ... we conclude that BPA may inhibit lipid recruitment during starvation in Drosophila."
Fungal compound as possible environmental risk factor for Parkinson's Disease.
Inamdar AA, Hossain MM, Bernstein AI, Miller GW, Richardson JR, Bennett JW. Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. Proc Natl Acad Sci U S A. 2013 Nov 11. PMID: 24218591.
From the abstract: "... To date ... suspected environmental risk factors [for Parkinson's Disease] have been man-made chemicals. In this report, we demonstrate ... that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. ..."
From the abstract: "... To date ... suspected environmental risk factors [for Parkinson's Disease] have been man-made chemicals. In this report, we demonstrate ... that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. ..."
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