Tuesday, December 17, 2013

Neurofibromatosis and fly studies.

Walker JA, Gouzi JY, Long JB, Huang S, Maher RC, Xia H, Khalil K, Ray A, Van Vactor D, Bernards R, Bernards A. Genetic and Functional Studies Implicate Synaptic Overgrowth and Ring Gland cAMP/PKA Signaling Defects in the Drosophila melanogaster Neurofibromatosis-1 Growth Deficiency. PLoS Genet. 2013 Nov;9(11):e1003958. PMID: 24278035; PMCID: PMC3836801.

Drosophila models of diabetes.

He BZ, Ludwig MZ, Dickerson DA, Barse L, Arun B, Vilhjálmsson BJ, Park SY, Tamarina NA, Selleck SB, Wittkopp PJ, Bell GI, Kreitman M. Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin. Genetics. 2013 Nov 26. PMID: 24281155.

Park SY, Ludwig MZ, Tamarina NA, He BZ, Carl SH, Dickerson DA, Barse L, Arun B, Williams CL, Miles CM, Philipson LH, Steiner DF, Bell GI, Kreitman M. Genetic Complexity in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin. Genetics. 2013 Nov 26. PMID: 24281154.

These studies utilize the Drosophila Genome Reference Panel from the MacKay lab.

DGRP information page at the MacKay lab
DGRP search page
Nature paper describing the resource

Hippo pathway and cancer.

Michaloglou C, Lehmann W, Martin T, Delaunay C, Hueber A, Barys L, Niu H, Billy E, Wartmann M, Ito M, Wilson CJ, Digan ME, Bauer A, Voshol H, Christofori G, Sellers WR, Hofmann F, Schmelzle T. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One. 2013 Apr 16;8(4):e61916. PMID: 23613971; PMCID: PMC3628344.

Fly heart diease model. Impaired Traponin-T.

Cozhimuttam Viswanathan M, Kaushik G, Engler AJ, Lehman WJ, Cammarato A. A Drosophila Melanogaster Model of Diastolic Dysfunction and Cardiomyopathy Based on Impaired Troponin-T Function. Circ Res. 2013 Nov 12. PMID: 24221941.

Flies & Neurodegeration. Database, recent reports and review.

Na D, Rouf M, O Kane CJ, Rubinsztein DC, Gsponer J. NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases. BMC Med Genomics. 2013 Nov 14;6(1):52. PMID: 24229347; PMCID: PMC3833180.

Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H, Ginggen A, De Strooper B, Tardy Y, Verstreken P. Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model. PLoS One. 2013 Nov 11;8(11):e78562. PMID: 24244323; PMCID: PMC3823844.

Riemensperger T, Issa AR, Pech U, Coulom H, Nguyễn MV, Cassar M, Jacquet M, Fiala A, Birman S. A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 2013 Nov 27;5(4):952-60. PMID: 24239353.

Moran MT, Tare M, Kango-Singh M, Singh A. Homeotic Gene teashirt (tsh) Has a Neuroprotective Function in Amyloid-Beta 42 Mediated Neurodegeneration. PLoS One. 2013 Nov 25;8(11):e80829. PMID: 24282556; PMCID: PMC3840013.

Prüßing K, Voigt A, Schulz JB. Drosophila melanogaster as a model organism for Alzheimer's disease. Mol Neurodegener. 2013 Nov 22;8(1):35. PMID: 24267573.