Monday, March 31, 2014

Effect of a compound found in green tea tests with fly Parkinson's model

Siddique YH, Jyoti S, Naz F. Effect of epicatechin gallate dietary supplementation on transgenic Drosophila model of Parkinson's disease. J Diet Suppl. 2014 Jun;11(2):121-30. PMID: 24670116.

Sunday, March 30, 2014

Two studies related to Alzheimer's Disease

Wang X, Kim JR, Lee SB, Kim YJ, Jung MY, Kwon HW, Ahn YJ. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14(1):88.PMID: 24597901; PMCID: PMC3946151.

Shaw JL, Chang KT. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. PLoS Genet. 2013;9(9):e1003792. PMID: 24086147; PMCID: PMC3784514.

Suppression of degeneration in a fly model of spinocerebellar ataxia

Cushman-Nick M, Bonini NM, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. PLoS Genet. 2013;9(9):e1003781. PMID: 24039611; PMCID: PMC3764203.

Flies, zinc binding, mitochondria and ALS

Bahadorani S, Mukai ST, Rabie J, Beckman JS, Phillips JP, Hilliker AJ. Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction. Neurobiol Aging. 2013 Oct;34(10):2322-30. PMID: 23601674.

Fly model of myotonic dystrophy type 1

Picchio L, Plantie E, Renaud Y, Poovthumkadavil P, Jagla K. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Hum Mol Genet. 2013 Jul 15;22(14):2795-810. PMID: 23525904.

Drosophila included in vitamin B study

Marzio A, Merigliano C, Gatti M, Vernì F. Sugar and chromosome stability: clastogenic effects of sugars in vitamin b6-deficient cells. PLoS Genet. 2014 Mar 20;10(3):e1004199. PMID: 24651653; PMCID: PMC3961173.

Loss-of-function in flies included in study of inherited cerebral palsy

Kruer MC, Jepperson T, Dutta S, Steiner RD, Cottenie E, Sanford L, Merkens M, Russman BS, Blasco PA, Fan G, Pollock J, Green S, Woltjer RL, Mooney C, Kretzschmar D, Paisán-Ruiz C, Houlden H. Mutations in γ adducin are associated with inherited cerebral palsy. Ann Neurol. 2013 Dec;74(6):805-14. PMID: 23836506; PMCID: PMC3952628.

Patient alleles functionally tested in flies--cancer-related study

Gavilan HS, Kulikauskas RM, Gutmann DH, Fehon RG. In Vivo Functional Analysis of the Human NF2 Tumor Suppressor Gene in Drosophila. PLoS One. 2014 Mar 4;9(3):e90853. PMID: 24595234; PMCID: PMC3942481.

From the abstract:  "... Interestingly, we found that a patient-derived missense allele, NF2L64P, appears to be temperature sensitive. ..."

Thursday, March 20, 2014

Fly models, cancer and aneuploidy--a review

Milán M, Clemente-Ruiz M, Dekanty A, Muzzopappa M. Aneuploidy and tumorigenesis in Drosophila. Semin Cell Dev Biol. 2014 Mar 15. pii: S1084-9521(14)00042-1. PMID: 24641887.

Wednesday, March 5, 2014

Review--flies and study of colorectal cancer

Bell GP, Thompson BJ. Colorectal cancer progression: Lessons from Drosophila? Semin Cell Dev Biol. 2014 Feb 27. pii: S1084-9521(14)00019-6. PMID: 24583474.

Reveiw--model systems in the study of autism spectrum disorders

Doll CA, Broadie K. Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models. Front Cell Neurosci. 2014 Feb 7;8:30. eCollection 2014. Review. PMID: 24570656; PMCID: PMC3916725.

Autophagy and neurodenenerative disease

Bakhoum MF, Bakhoum CY, Ding Z, Carlton SM, Campbell GA, Jackson GR. Evidence for autophagic gridlock in aging and neurodegeneration. Transl Res. 2014 Feb 3. pii: S1931-5244(14)00048-6. PMID: 24561013.

Flies used for signal pathway analysis in cancer-related study

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest. 2013 Nov 1;123(11):4681-94. PubMed PMID: 24216479; PubMed Central PMCID: PMC3809775.

Monday, March 3, 2014

Fly cell study identifies conserved host cell factors related to West Nile Virus infection

Yasunaga A, Hanna SL, Li J, Cho H, Rose PP, Spiridigliozzi A, Gold B, Diamond MS, Cherry S. Genome-Wide RNAi Screen Identifies Broadly-Acting Host Factors That Inhibit Arbovirus Infection. PLoS Pathog. 2014 Feb 13;10(2):e1003914. PMID: 24550726; PMCID: PMC3923753.

From the abstract:  "Investigation of two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1, in the Tip60 complex, demonstrated they contributed to antiviral defense at the organismal level in adult flies, in mosquito cells, and in mammalian cells. These data suggest the existence of broadly acting and functionally conserved antiviral genes and pathways that restrict virus infections in evolutionarily divergent hosts."