Friday, September 28, 2012

SMBA & Poly-Q study. Recent report.

Jochum T, Ritz ME, Schuster C, Funderburk SF, Jehle K, Schmitz K, Brinkmann F, Hirtz M, Moss D, Cato AC. Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures. Biochim Biophys Acta. 2012 Jun;1822(6):1070-8. PubMed PMID: 22366762.

The authors indicate that they used two existing fly stocks, pUAST-ARQ22 and pUAST-ARQ22dm, and generated two new transgenic stocks, pUAST-ARQ1 and -ARQ65, for the study. These are pathogenic forms of the human androgen receptor protein. See this FlyBase page for more info on human AR transgenic flies. To induce expression of the AR forms, these authors used the OK371-GAL4 driver fly stock.

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