Monday, September 24, 2012

A-beta inhibitor tested in a fly model of Alzheimer's disease. Recent report.

McKoy AF, Chen J, Schupbach T, Hecht MH. A novel inhibitor of Aβ peptide aggregation: from high throughput screening to efficacy in an animal model for Alzheimer's disease. J Biol Chem. 2012 Sep 19. PubMed PMID: 22992731.

The fly model is described in the methods section as follows "female flies carrying the Aβ42 or Aβ42/E22G transgene under the UAS promoter in a homozygous condition ... crossed with male flies carrying the driver Elav[c155]-Gal4 on their X- chromosome."

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