Friday, September 21, 2012

Fly wing genetic study helps define epigenetic network involved in cognition. Recent report.

This paper provides a nice example of how genetic studies in the fly can inform the interpretation of human disease-related next generation sequencing (NGS) results. 

Their Supplemental Table 7 lists the fly stocks they used in the study.

Kleefstra T, Kramer JM, Neveling K, Willemsen MH, Koemans TS, Vissers LE, Wissink-Lindhout W, Fenckova M, van den Akker WM, Kasri NN, Nillesen WM, Prescott T, Clark RD, Devriendt K, van Reeuwijk J, de Brouwer AP, Gilissen C, Zhou H, Brunner HG, Veltman JA, Schenck A, van Bokhoven H. Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Am J Hum Genet. 2012 Jul 13;91(1):73-82. PubMed PMID: 22726846; PubMed Central PMCID: PMC3397275.

From the paper:

"Drosophila genetic interaction studies with established disease genes thus provide an efficient and, in our opinion, urgently required method of discriminating between rare or even unique benign DNA variants and causative mutations in the NGS era."

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