Wednesday, September 19, 2012
Fly study links Ellis-van Creveld syndrome genes to Hedgehog pathway. Recent report.
Yang C, Chen W, Chen Y, Jiang J. Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res. 2012 Sep 18. doi: 10.1038/cr.2012.134. PubMed PMID: 22986504.
Additional ciliopathies for which there are putative fly orthologs of the human disease-associated genes include Ciliary Dykinesia, Joubert Syndrome and Bardet-Biedl Syndrome.