Friday, September 21, 2012

Crawling assay useful for assessing neurological disorder fly models. Recent report.

It's not just about your model fly. It's also about how you test it. 

This report describes a quantitative larval crawling assay that reveals impaired crawling in disease models of Alzheimer's disease (AD) and Fragile X syndrome. They also note that their findings with shaggy mutant animals might be relevant to the use of GSK-3 inhibitors in treating AD.

Jakubowski B, Longoria R, Shubeita G. A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes. Fly (Austin). 2012 Sep 19;6(4). PubMed PMID: 22992470.

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