Tuesday, September 25, 2012

LRRK2 as a critical regulator of EndophilinA. Parkinson's model in action. Recent report.

From the abstract: "LRRK2-mediated EndoA phosphorylation has profound effects on EndoA-dependent membrane tubulation and membrane association ... and on synaptic vesicle endocytosis at Drosophila neuromuscular junctions in vivo." The authors report use of both loss-of-function and gain-of-function genetic approaches in the study.

Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P. LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis. Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022. PubMed PMID: 22998870.

Click to see a post on a loss-of-function fly study of Lrrk2.
Or other posts on Parkinson's Disease.
Or other posts on neurodegeneration diseases of many types.

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