This study describes analysis of loss-of-function of the Drosophila ortholog of LRRK2 (dLRRK), as well as analysis of the effects of over-expression of wild-type Drosophila and human LRRK2, and a pathogenic mutant form (hLRRK2-G2019S). The authors point out that LRRK2 is associated with familial and sporadic forms of Parkinson's Disease.
Lee S, Imai Y, Gehrke S, Liu S, Lu B. The synaptic function of LRRK2. Biochem Soc Trans. 2012 Oct 1;40(5):1047-51. PubMed PMID: 22988863.