Friday, March 22, 2013

Drosophila & kidney stones. Recent review.

Miller J, Chi T, Kapahi P, Kahn AJ, Kim MS, Hirata T, Romero MF, Dow JA, Stoller ML. Drosophila Melanogaster as an Emerging Translational Model of Human Nephrolithiasis. J Urol. 2013 Mar 7. doi:pii: S0022-5347(13)03645-8. PubMed PMID: 23500641.

From the abstract:  "The ability to readily manipulate and quantify stone formation in D. melanogaster models of human nephrolithiasis presents the urologic community with a unique opportunity to increase our understanding of this enigmatic disease."

To view more blog posts on kidney stones (nephrolithiasis) click here.

Thursday, March 7, 2013

TBI, SCI & the fly. Recent review.

Nerve injury includes traumatic brain injury (TBI) and spinal cord injury (SCI).

Fang Y, Bonini NM. Axon degeneration and regeneration: insights from Drosophila models of nerve injury. Annu Rev Cell Dev Biol. 2012;28:575-97. doi: 10.1146/annurev-cellbio-101011-155836. Review. PubMed PMID: 22831639.

From the abstract: "Genetically approachable model organisms such as Drosophila melanogaster, the fruit fly, have proven exceptionally successful in modeling human neurodegenerative diseases. More recently, this success has been extended into the field of acute axon injury and regeneration."

Flies & Alcoholism. Recent review.

Robinson BG, Atkinson NS. Is alcoholism learned? Insights from the fruit fly. Curr Opin Neurobiol. 2013 Feb 22. PubMed PMID: 23462335.

Troyer syndrome. New fly model. Recent report.

Troyer syndrome is one of several hereditary spastic paraplegias.

Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S. Spartin Regulates Synaptic Growth and Neuronal Survival by
Inhibiting BMP-Mediated Microtubule Stabilization. Neuron. 2013 Feb 20;77(4):680-95. doi: 10.1016/j.neuron.2012.12.015. PubMed PMID: 23439121.

Wednesday, March 6, 2013

Uncoupling of snRNPs from SMA. Recent report.

This paper is now freely available in PubMed Central.

Praveen K, Wen Y, Matera AG. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012 Jun 28;1(6):624-31. PMID: 22813737; PMCID: PMC3405901.

From the abstract: "These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects."

See also this posted paper on splicing & SMA.
Or all blog posts on SMA.

Fly models & Alzheimers. Recent report.

Hopkins PC. Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein. PLoS One. 2013;8(2):e55810. doi: 10.1371/journal.pone.0055810. PubMed PMID: 23409049; PubMed Central PMCID: PMC3567013.

Aiming to kill mosquitoes, not flies (or people). Recent Report.

The health relevance of Drosophila as a model system extends beyond conserved human genes. This report describes testing compounds in mosquito, Drosophila and human cells in an effort to identify compounds that kill mosquitoes without affecting related insects like fruit flies, or humans.

O'Neal MA, Posner BA, Coates CJ, Abrams JM. A Cell-Based Screening Platform Identifies Novel Mosquitocidal Toxins. J Biomol Screen. 2013 Feb 13. PubMed PMID: 23407365.