This study describes a new fly model based on introduction of a human disease-associated missense mutation (E706K) in myosin heavy chain IIa. The mutant form was introduced via P-element transformation and crossed into an Mhc null mutant background.
Wang Y, Melkani GC, Suggs JA, Melkani A, Kronert WA, Cammarato A, Bernstein SI. Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness. Mol Biol Cell. 2012 Jun;23(11):2057-65. Epub 2012 Apr 11. PubMed PMID: 22496423; PubMed Central PMCID: PMC3364171.
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