Monday, September 17, 2012

Fly and mouse models of Alzheimer's Disease. Therapeutics development. Recent report.

Scherzer-Attali R, Farfara D, Cooper I, Levin A, Ben-Romano T, Trudler D, Vientrov M, Shaltiel-Karyo R, Shalev DE, Segev-Amzaleg N, Gazit E, Segal D, Frenkel D. Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model. Neurobiol Dis. 2012 Jun;46(3):663-72. PubMed PMID: 22449754.

The fly model is described in the paper this way:  "Male flies carrying the driver elav-c155-Gal4 (on their X chromosome) were crossed to females carrying the Aβ1–42 transgene (located on an  autosome) under the UAS promoter in a homozygous condition. This resulted in first generation (F1) female offspring expressing Aβ1–42 in their nervous system. ... Male F1 offspring, which carried the Aβ1–42 transgene but did not express it (because they lacked the Gal4 driver) served as a control."

Resources related Alzheimer's Disease:

Alzheimer Research Forum
BDSC's AD fly stocks page
Past posts on AD

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