Monday, October 1, 2012

A-beta and zinc transport. Recent report.

This open access paper focuses on the potential role of a zinc transporter in Alzheimer's disease.

Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, Zhou B. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. PLoS Genet. 2012;8(4):e1002683. PubMed PMID: 22570624; PubMed Central PMCID: PMC3343105.

They indicate that they use the fly A-beta42 model reported here:  Iijima et al. (2008) Abeta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila. PLoS ONE 3: e1703. PubMed ID: 18301778 PubMed Central ID: PMC225077

Click to view a recent post on a chemical inhibitor of A-beta.

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