This recent review discusses what's known and open questions regarding host-pathogen interactions as studied in model systems, specifically with biofilms in mind.
Edwards S, Kjellerup BV. Exploring the applications of invertebrate host-pathogen models for in vivo biofilm infections. FEMS Immunol Med Microbiol. 2012 Jul;65(2):205-14. doi: 10.1111/j.1574-695X.2012.00975.x. Review. PubMed PMID: 22533965.
Among other things, the review includes a discussion of a fly-based
approach to sub-categorizing bacteria isolated from infections in cystic
Sibley CD, Duan K, Fischer C, Parkins MD, Storey DG, Rabin HR, Surette MG. Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLoS Pathog. 2008 Oct;4(10):e1000184. Epub 2008 Oct 24. PubMed PMID: 18949036; PubMed Central PMCID: PMC2566602.