Thursday, October 4, 2012

Fly model of muscular dystrophy and cardiomyopathy.

These reports utilize flies mutant for sarcoglycan (Sgcd), which the authors describe as a fly model of muscular dystrophy and cardiomyopathy. Fly Sgcd is related to human SGCD

Both papers are freely available.

Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 1;16(23):2933-43. PubMed PMID: 17855453.

Goldstein JA, Kelly SM, LoPresti PP, Heydemann A, Earley JU, Ferguson EL, Wolf MJ, McNally EM. SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. Hum Mol Genet. 2011 Mar 1;20(5):894-904. PubMed PMID: 21138941; PubMed Central PMCID: PMC3033181.

Here's an alignment of fly Sgcd and human SGCD, as well as other info, from DIOPT (click "view" from DIOPT or the DIOPT score from DIOPT-DIST to reach this page).


No comments:

Post a Comment