Tuesday, October 9, 2012

Fly genetic study and gastric cancer. Recent report.

These authors describe screening for modifiers of the effects of expression of gastric cancer-associated mutant gene forms in the fly eye. Follow-up included a chick assay of angiogenesis.

Caldeira J, Simões-Correia J, Paredes J, Pinto MT, Sousa S, Corso G, Marrelli D, Roviello F, Pereira PS, Weil D, Oliveira C, Casares F, Seruca R. CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut. 2012 Aug;61(8):1115-23. PubMed PMID: 22052064.

The candidate they followed up on is the fly orb gene (CPEB1 in humans).

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