Thursday, October 18, 2012

Huntington's Disease. Fly model in action. Recent report.

These authors report a study in which they supplement studies in mammalian models with an assay in "eye degeneration of eye-specific mtHtt (Q127) expressing flies."

Lee J, Hong YK, Jeon GS, Hwang YJ, Kim KY, Seong KH, Jung MK, Picketts DJ, Kowall NW, Cho KS, Ryu H. ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. Cell Death Differ. 2012 Jul;19(7):1109-16. doi: 10.1038/cdd.2011.196. PubMed PMID: 22240898; PubMed Central PMCID: PMC3374076.

Similar fly stocks in which expanded repeat forms of human HTT are expressed in the eye or via an inducible promoter are available from the BDSC.

No comments:

Post a Comment