Tuesday, August 7, 2012

Fly models of dilated cardiomyopathies. Recent review.

Wolf MJ. Modeling Dilated Cardiomyopathies in Drosophila. Trends Cardiovasc Med. 2012 Aug 2. PubMed PMID: 22863366.

The review includes a nice figure of the fly cardiovascular system (Fig. 2) and this statement in the Conclusions section:
Although the adult fly heart is a single cell layer thick and does not possess noncardiac cells found in mammalian hearts, the Drosophila model provides a system to examine the direct effects of gene mutations on size, morphology, and function of cardiomyocytes ... Ongoing investigations of the fly as a model for human cardiomyopathies have the potential to uncover new, fundamental mechanisms that are responsible for human cardiovascular diseases.

No comments:

Post a Comment