Wednesday, August 29, 2012

Signal-mediated growth control and mitochondria. Recent report.

This recent report links mitochondrial fusion and cancer-relevant, signal-mediated growth control by the hippo signal transduction pathway. 

A link to mitochondria sounds familiar? Mitochondrial dynamics were recently linked to neurodegenerative disease as well--see this post.

Nagaraj R, Gururaja-Rao S, Jones KT, Slattery M, Negre N, Braas D, Christofk H, White KP, Mann R, Banerjee U. Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes Dev. 2012 Aug 27. PubMed PMID: 22925885

The hippo signaling pathway has its own Wikipedia page. And as of this posting, it's been nominated but not yet created as a pathway at WikiPathways.

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