Picchio L, Plantie E, Renaud Y, Poovthumkadavil P, Jagla K. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Hum Mol Genet. 2013 Apr 3. PubMed PMID: 23525904.
From the abstract: "we found the calcium pump dSERCA as a Mbl splice target and show that the membrane dSERCA isoform is sufficient to rescue a DM1-induced hypercontraction phenotype in a Drosophila model."
Friday, April 12, 2013
Thursday, April 4, 2013
ALS & the fly. Human disease-associated SOD1 mutations in the fly. Recent report.
Kumimoto EL, Fore TR, Zhang B. Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila. G3 (Bethesda). 2013 Mar 11. PMID: 23550139.
Friday, March 22, 2013
Drosophila & kidney stones. Recent review.
Miller J, Chi T, Kapahi P, Kahn AJ, Kim MS, Hirata T, Romero MF, Dow JA, Stoller ML. Drosophila Melanogaster as an Emerging Translational Model of Human Nephrolithiasis. J Urol. 2013 Mar 7. doi:pii: S0022-5347(13)03645-8. PubMed PMID: 23500641.
From the abstract: "The ability to readily manipulate and quantify stone formation in D. melanogaster models of human nephrolithiasis presents the urologic community with a unique opportunity to increase our understanding of this enigmatic disease."
To view more blog posts on kidney stones (nephrolithiasis) click here.
From the abstract: "The ability to readily manipulate and quantify stone formation in D. melanogaster models of human nephrolithiasis presents the urologic community with a unique opportunity to increase our understanding of this enigmatic disease."
To view more blog posts on kidney stones (nephrolithiasis) click here.
Thursday, March 7, 2013
TBI, SCI & the fly. Recent review.
Nerve injury includes traumatic brain injury (TBI) and spinal cord injury (SCI).
Fang Y, Bonini NM. Axon degeneration and regeneration: insights from Drosophila models of nerve injury. Annu Rev Cell Dev Biol. 2012;28:575-97. doi: 10.1146/annurev-cellbio-101011-155836. Review. PubMed PMID: 22831639.
From the abstract: "Genetically approachable model organisms such as Drosophila melanogaster, the fruit fly, have proven exceptionally successful in modeling human neurodegenerative diseases. More recently, this success has been extended into the field of acute axon injury and regeneration."
Fang Y, Bonini NM. Axon degeneration and regeneration: insights from Drosophila models of nerve injury. Annu Rev Cell Dev Biol. 2012;28:575-97. doi: 10.1146/annurev-cellbio-101011-155836. Review. PubMed PMID: 22831639.
From the abstract: "Genetically approachable model organisms such as Drosophila melanogaster, the fruit fly, have proven exceptionally successful in modeling human neurodegenerative diseases. More recently, this success has been extended into the field of acute axon injury and regeneration."
Flies & Alcoholism. Recent review.
Robinson BG, Atkinson NS. Is alcoholism learned? Insights from the fruit fly. Curr Opin Neurobiol. 2013 Feb 22. PubMed PMID: 23462335.
Troyer syndrome. New fly model. Recent report.
Troyer syndrome is one of several hereditary spastic paraplegias.
Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S. Spartin Regulates Synaptic Growth and Neuronal Survival by
Inhibiting BMP-Mediated Microtubule Stabilization. Neuron. 2013 Feb 20;77(4):680-95. doi: 10.1016/j.neuron.2012.12.015. PubMed PMID: 23439121.
Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S. Spartin Regulates Synaptic Growth and Neuronal Survival by
Inhibiting BMP-Mediated Microtubule Stabilization. Neuron. 2013 Feb 20;77(4):680-95. doi: 10.1016/j.neuron.2012.12.015. PubMed PMID: 23439121.
Wednesday, March 6, 2013
Uncoupling of snRNPs from SMA. Recent report.
This paper is now freely available in PubMed Central.
Praveen K, Wen Y, Matera AG. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012 Jun 28;1(6):624-31. PMID: 22813737; PMCID: PMC3405901.
From the abstract: "These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects."
See also this posted paper on splicing & SMA.
Or all blog posts on SMA.
Praveen K, Wen Y, Matera AG. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012 Jun 28;1(6):624-31. PMID: 22813737; PMCID: PMC3405901.
From the abstract: "These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects."
See also this posted paper on splicing & SMA.
Or all blog posts on SMA.
Subscribe to:
Posts (Atom)