Monday, August 27, 2012

Diacylglycerol kinase and Huntingtin toxicity. Recent report.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. J Biol Chem. 2012 Jun 15;287(25):21204-13. PubMed PMID: 22511757; PubMed Central PMCID: PMC3375542.

The fly model used in the study (from their Materials and Methods section):  "The nervous system driver line elav-GALc155 was obtained from the Bloomington Drosophila Stock Center at University of Indiana. The inducible shRNA line targeting the Drosophila homolog of DGKϵ (4659GD) was obtained from the Vienna Drosophila RNAi Center."

Related resources: BDSC's page on Huntington's Disease-related fly stocks.
See also posts on DK deficiency.
See also all posts on Huntingtons disease.

No comments:

Post a Comment