Proteomics analysis used to explore conserved networks relavant to Parkinson's Disease

Zhang S, Xie J, Xia Y, Yu S, Gu Z, Feng R, Luo G, Wang D, Wang K, Jiang M, Cheng X, Huang H, Zhang W, Wen T. LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration. Sci Rep. 2015 Jul 29;5:12564. doi: 10.1038/srep12564. PMID: 26220523

From the abstract: "Parkinson's disease (PD) is a movement disorder due to the loss of dopaminergic (DA) neurons in the substantia nigra. Alpha-synuclein phosphorylation and α-synuclein inclusion (Lewy body) become a main contributor, but little is known about their formation mechanism. Here we used protein expression profiling of PD to construct a model of their signalling network from drsophila to human and nominate major nodes that regulate PD development. ..."