Bunker BD, Nellimoottil TT, Boileau RM, Classen AK, Bilder D. The transcriptional response to tumorigenic polarity loss in Drosophila. Elife. 2015 Feb 26;4. PMID: 25719210; PMCID: PMC4369581.
From the abstract: "Loss of polarity correlates with progression of epithelial cancers, but
how plasma membrane misorganization drives oncogenic transcriptional
events remains unclear. ... RNA profiling of Scrib mutant tumors
reveals multiple signatures of neoplasia, including altered metabolism
and dedifferentiation. ... We
identified a polarity-responsive enhancer in upd3, which is activated in
a coincident manner by both JNK-dependent Fos and aPKC-mediated Yki
transcription. This enhancer, and Scrib mutant overgrowth in general,
are also sensitive to activity of the Polycomb Group (PcG), suggesting
that PcG attenuation upon polarity loss potentiates select targets for
activation by JNK and Yki. Our results link epithelial organization to
signaling and epigenetic regulators that control tissue repair programs,
and provide insight into why epithelial polarity is tumor-suppressive."
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