Men TT, Thanh DN, Yamaguchi M, Suzuki T, Hattori G, Arii M, Huy NT, Kamei K. A Drosophila Model for Screening Antiobesity Agents. Biomed Res Int. 2016;2016:6293163. PMID: 27247940.
From the abstract: "... The brummer (bmm) gene in Drosophila melanogaster is known to be homologous with human adipocyte triglyceride lipase, which is related to the regulation of lipid storage. We established a Drosophila model for monitoring bmm expression by introducing the green fluorescent protein (GFP) gene as a downstream reporter of the bmm promoter. ... The Drosophila flies given high-glucose diets showed higher lipid contents, indicating the obesity phenotype; this was suggested by a weaker intensity of the GFP signal as well as reduced bmm mRNA expression. These results demonstrated that the transgenic Drosophila model established in this study is useful for screening antiobesity agents. We also report the effects of oral administration of histone deacetylase inhibitors and some vegetables on the bmm promoter activity."
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