Katzenberger RJ, Loewen CA, Bockstruck RT, Woods MA, Ganetzky B, Wassarman DA. A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila. J Vis Exp. 2015 Jun 30;(100):e52905. doi: 10.3791/52905. Erratum in: J Vis Exp. 2015;(101):e5744. Ganetky, Barry [corrected to Ganetzky, Barry]. PMID: 26168076.
From the abstract: "Traumatic brain injury (TBI) affects millions of people each year, causing impairment of physical, cognitive, and behavioral functions and death. Studies using Drosophila have contributed important breakthroughs in understanding neurological processes. Thus, with the goal of understanding the cellular and molecular basis of TBI pathologies in humans, we developed the High Impact Trauma (HIT) device to inflict closed head TBI in flies. ... the HIT device can be used to perform large-scale genetic screens to understand the genetic basis of TBI pathologies."
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