Review of drug discovery using model organisms including Drosophila

Strange K. Drug Discovery in Fish, Flies, and Worms. ILAR J. 2016 Dec;57(2):133-143. PMID: 28053067.

From the abstract: "Nonmammalian model organisms ... provide numerous experimental advantages for drug discovery including genetic and molecular tractability, amenability to high-throughput screening methods and reduced experimental costs and increased experimental throughput compared to traditional mammalian models. ... This review will provide an overview of C. elegans, Drosophila, and zebrafish biology and husbandry and will discuss how these models are being used for phenotype-based drug screening and for identification of drug targets and mechanisms of action. ..."