Nagoshi E. Drosophila Models of Sporadic Parkinson's Disease. Int J Mol Sci. 2018 Oct 26;19(11). pii: E3343. doi: 10.3390/ijms19113343. PMID: 30373150; PMCID: PMC6275057.
From the abstract: "Parkinson's disease (PD) is the most common cause of movement disorders ... It is increasingly recognized as a complex group of disorders ... With the exception of the rare monogenic forms, the majority of PD cases result from an interaction between multiple genetic and environmental risk factors. The search for these risk factors and the development of preclinical animal models are in progress ... This review summarizes the studies that capitalize on modeling sporadic (i.e., nonfamilial) PD using Drosophila melanogaster and discusses their methodologies, new findings, and future perspectives."
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