Several new studies and a review related to Alzheimer's disease and other neurodegenerative and age-related disorders

Goldberg J, Currais A, Prior M, Fischer W, Chiruta C, Ratliff E, Daugherty D, Dargusch R, Finley K, Esparza-Moltó PB, Cuezva JM, Maher P, Petrascheck M, Schubert D. The mitochondrial ATP synthase is a shared drug target for aging and dementia. Aging Cell. 2018 Apr;17(2). PubMed PMID: 29316249; PubMed Central PMCID: PMC5847861.

Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 Aug 13;28(7):1799-1813.e5. PubMed PMID: 31412248; PubMed Central PMCID:
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Yang L, Cao Y, Zhao J, Fang Y, Liu N, Zhang Y. Multidimensional proteomics identifies declines in protein homeostasis and mitochondria as early signals for normal aging and age-associated disease in Drosophila. Mol Cell Proteomics. 2019 Aug 21. pii: mcp.RA119.001621. PubMed PMID: 31434710.

Park SY, Seo J, Chun YS. Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster. J Korean Med Sci. 2019 Aug 26;34(33):e225. doi: 10.3346/jkms.2019.34.e225. PubMed PMID: 31436053; PubMed Central PMCID: PMC6706347.

Sun M, Zhao Y, Han M, Zhang B, Zhang X, Zhang Q, Lim NK, Wang WA, Huang FD. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. J Alzheimers Dis. 2018;65(3):1001-1010. PubMed PMID: 30103315.

Passarella D, Goedert M. Beta-sheet assembly of Tau and neurodegeneration in Drosophila melanogaster. Neurobiol Aging. 2018 Dec;72:98-105. PubMed PMID: 30240946;
PubMed Central PMCID: PMC6327151.

Gusareva ES, Twizere JC, Sleegers K, Dourlen P, Abisambra JF, Meier S, Cloyd R, Weiss B, Dermaut B, Bessonov K, et al. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiol Aging. 2018 Dec;72:188.e3-188.e12. PubMed PMID: 30201328.

Jantrapirom S, Lo Piccolo L, Yamaguchi M. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Int J Mol Sci. 2019 Apr 17;20(8). pii: E1893. Review. PubMed PMID: 30999567; PubMed Central PMCID: PMC6514573.

Bajracharya R, Youngson NA, Ballard JWO. Dietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson's Disease. Int J Mol Sci. 2019 Apr 15;20(8). pii: E1850. doi: 10.3390/ijms20081850. Review. PubMed PMID: 30991634; PubMed Central PMCID: PMC6514887.