Cells. 2021 Sep 10;10(9):2387. doi: 10.3390/cells10092387.
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.
Rambur A, Vialat M, Beaudoin C, Lours-Calet C, Lobaccaro JM, Baron S, Morel L, de Joussineau C
Author information:
(1)Rosalind and Morris Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montréal, QC H3A 1A3, Canada.
(2)Institut de Génétique, Reproduction et Développement, Université Clermont Auvergne, CNRS UMR6293, INSERM U1103, 28 Place Henri Dunant, BP38, 63001 Clermont-Ferrand, France.
Abstract: "Prostate cancer is the most common cancer in aging men. ... there are still few effective treatments to cure its aggressive and metastatic stages. ... multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. ... this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model ..."
DOI: 10.3390/cells10092387
PMID: 34572036
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