These authors describe screening for modifiers of the effects of expression of gastric cancer-associated mutant gene forms in the fly eye. Follow-up included a chick assay of angiogenesis.
Caldeira J, Simões-Correia J, Paredes J, Pinto MT, Sousa S, Corso G, Marrelli D, Roviello F, Pereira PS, Weil D, Oliveira C, Casares F, Seruca R. CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut. 2012 Aug;61(8):1115-23. PubMed PMID: 22052064.
The candidate they followed up on is the fly orb gene (CPEB1 in humans).
Tuesday, October 9, 2012
Flies, Smoke and Parkinson's. Recent Report.
Hill-Burns EM, Singh N, Ganguly P, Hamza TH, Montimurro J, Kay DM, Yearout D, Sheehan P, Frodey K, McLear JA, Feany MB, Hanes SD, Wolfgang WJ, Zabetian CP, Factor SA, Payami H. A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease. Pharmacogenomics J. 2012 Oct 2. doi: 10.1038/tpj.2012.38. PubMed PMID: 23032990.
Thursday, October 4, 2012
Fly model of muscular dystrophy and cardiomyopathy.
These reports utilize flies mutant for sarcoglycan (Sgcd), which the authors describe as a fly model of muscular dystrophy and cardiomyopathy. Fly Sgcd is related to human SGCD.
Both papers are freely available.
Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 1;16(23):2933-43. PubMed PMID: 17855453.
Goldstein JA, Kelly SM, LoPresti PP, Heydemann A, Earley JU, Ferguson EL, Wolf MJ, McNally EM. SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. Hum Mol Genet. 2011 Mar 1;20(5):894-904. PubMed PMID: 21138941; PubMed Central PMCID: PMC3033181.
Here's an alignment of fly Sgcd and human SGCD, as well as other info, from DIOPT (click "view" from DIOPT or the DIOPT score from DIOPT-DIST to reach this page).
Both papers are freely available.
Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 1;16(23):2933-43. PubMed PMID: 17855453.
Goldstein JA, Kelly SM, LoPresti PP, Heydemann A, Earley JU, Ferguson EL, Wolf MJ, McNally EM. SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. Hum Mol Genet. 2011 Mar 1;20(5):894-904. PubMed PMID: 21138941; PubMed Central PMCID: PMC3033181.
Here's an alignment of fly Sgcd and human SGCD, as well as other info, from DIOPT (click "view" from DIOPT or the DIOPT score from DIOPT-DIST to reach this page).
Tuesday, October 2, 2012
Inventory of fly peroxisomal proteins. Links to diseases. Recent report.
This recent paper catalogs fly peroxisomal proteins.
Faust JE, Verma A, Peng C, McNew JA. An Inventory of Peroxisomal Proteins and Pathways in Drosophila melanogaster. Traffic. 2012 Oct;13(10):1378-92. doi: 10.1111/j.1600-0854.2012.01393.x. PubMed PMID: 22758915; PubMed Central PMCID: PMC3443258.
Disruption of peroxisomal-related factors in humans can cause peroxisomal biogenesis disorders such as Zellweger syndrome. Additional relevant disease terms include peroxisomal acyl-CoA oxidase deficiency, rhizomelic chondrodysplasia punctata, Refsum disease, and neonatal adrenoleukodystrophy. You can read about peroxisomal biogenesis disorders at Gene Reviews (includes information about human disease-associated genes).
Evolutionary conservation? The answer appears to be yes. From the paper, "We have identified all of the major vertebrate peroxisomal pathways in Drosophila."
At least these three papers discuss fly models of peroxisomal biogenesis disorders.
Mast FD, Li J, Virk MK, Hughes SC, Simmonds AJ, Rachubinski RA. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Dis Model Mech. 2011 Sep-Oct;4(5):659-72. doi: 10.1242/dmm.007419. PubMed PMID: 21669930; PubMed Central PMCID: PMC3180231.
Nakayama M, Sato H, Okuda T, Fujisawa N, Kono N, Arai H, Suzuki E, Umeda M, Ishikawa HO, Matsuno K. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. PLoS One. 2011;6(8):e22984. PubMed PMID: 21826223; PubMed Central PMCID: PMC3149631.
Chen H, Liu Z, Huang X. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Hum Mol Genet. 2010 Feb 1;19(3):494-505. PubMed PMID: 19933170.
Faust JE, Verma A, Peng C, McNew JA. An Inventory of Peroxisomal Proteins and Pathways in Drosophila melanogaster. Traffic. 2012 Oct;13(10):1378-92. doi: 10.1111/j.1600-0854.2012.01393.x. PubMed PMID: 22758915; PubMed Central PMCID: PMC3443258.
Disruption of peroxisomal-related factors in humans can cause peroxisomal biogenesis disorders such as Zellweger syndrome. Additional relevant disease terms include peroxisomal acyl-CoA oxidase deficiency, rhizomelic chondrodysplasia punctata, Refsum disease, and neonatal adrenoleukodystrophy. You can read about peroxisomal biogenesis disorders at Gene Reviews (includes information about human disease-associated genes).
Evolutionary conservation? The answer appears to be yes. From the paper, "We have identified all of the major vertebrate peroxisomal pathways in Drosophila."
At least these three papers discuss fly models of peroxisomal biogenesis disorders.
Mast FD, Li J, Virk MK, Hughes SC, Simmonds AJ, Rachubinski RA. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Dis Model Mech. 2011 Sep-Oct;4(5):659-72. doi: 10.1242/dmm.007419. PubMed PMID: 21669930; PubMed Central PMCID: PMC3180231.
Nakayama M, Sato H, Okuda T, Fujisawa N, Kono N, Arai H, Suzuki E, Umeda M, Ishikawa HO, Matsuno K. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. PLoS One. 2011;6(8):e22984. PubMed PMID: 21826223; PubMed Central PMCID: PMC3149631.
Chen H, Liu Z, Huang X. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Hum Mol Genet. 2010 Feb 1;19(3):494-505. PubMed PMID: 19933170.
Publication searches. Multiple tools.
A search with "Drosophila disease model" calls up different results in Quertle, Google Scholar and PubMed. And the three tools provide different search options. Check it out.
Monday, October 1, 2012
Cancer and the immune response. Recent report.
This recent report looks at the influence of infection in a fly model of cancer (Ras1[V12] model).
Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun 1;13(6):569-76. doi: 10.1038/embor.2012.44. PubMed PMID: 22498775; PubMed Central PMCID: PMC3367237.
Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun 1;13(6):569-76. doi: 10.1038/embor.2012.44. PubMed PMID: 22498775; PubMed Central PMCID: PMC3367237.
A-beta and zinc transport. Recent report.
This open access paper focuses on the potential role of a zinc transporter in Alzheimer's disease.
Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, Zhou B. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. PLoS Genet. 2012;8(4):e1002683. PubMed PMID: 22570624; PubMed Central PMCID: PMC3343105.
They indicate that they use the fly A-beta42 model reported here: Iijima et al. (2008) Abeta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila. PLoS ONE 3: e1703. PubMed ID: 18301778 PubMed Central ID: PMC225077
Click to view a recent post on a chemical inhibitor of A-beta.
Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, Zhou B. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. PLoS Genet. 2012;8(4):e1002683. PubMed PMID: 22570624; PubMed Central PMCID: PMC3343105.
They indicate that they use the fly A-beta42 model reported here: Iijima et al. (2008) Abeta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila. PLoS ONE 3: e1703. PubMed ID: 18301778 PubMed Central ID: PMC225077
Click to view a recent post on a chemical inhibitor of A-beta.
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