Thursday, September 5, 2013

Fly model of Alzheimer's disease is used to explore links to copper homeostasis.

Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, Wang W, Zhong Y, Zhou B. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013 Nov;34(11):2604-12. PMID: 23827522.

From the abstract:  "These results imply that copper may play a causative role in developing AD ... Early manipulation of brain copper uptake can have a great effect on Aβ pathology."

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