Tuesday, October 29, 2013

Fly study sheds light on Pink1/Parkin pathway. Recent report relevant to Parkinson's Disease.

de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis. 2013 Oct 24;4:e873. PMID: 24157867.

From the abstract:  We conclude that Ref(2)P [the fly ortholog of mammalian sequestrome-1 (p62/SQSTM1)] is a crucial downstream effector of a pathway involving Pink1 and Parkin and is responsible for the maintenance of a viable pool of cellular mitochondria by promoting their aggregation and autophagic clearance.

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