Wednesday, July 23, 2014

Research article and dispatch--Cancer-related study in flies

Herranz H, Weng R, Cohen SM. Crosstalk between Epithelial and Mesenchymal Tissues in Tumorigenesis and Imaginal Disc Development. Curr Biol. 2014 Jul 7;24(13):1476-84. PMID: 24980505.
From the abstract:
"... Here, we report a Drosophila genetic model of EGFR-driven tumorigenesis in which the neoplastic transformation depends on interaction between epithelial and mesenchymal cells. ... Tumorigenesis in this model co-opts a regulatory mechanism that is normally involved in controlling growth of the imaginal disc during development."

See also a dispatch on the article: Milán M. Tumor Models: Tumor-Stroma Interactions Drive Neoplastic Transformation in Drosophila. Curr Biol. 2014 Jul 21;24(14):R658-R659. PMID: 25050966.

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