Júnior FE, Macedo GE, Zemolin AP, Silva GF, Cruz LC, Boligon AA, de Menezes IR, Franco JL, Posser T. Oxidant effects and toxicity of Croton campestris in Drosophila melanogaster. Pharm Biol. 2016 Jul 14:1-10. PMID: 27417881.
From the abstract: "... Croton campestris ... is a species native to Northeast Brazil used by traditional communities for the treatment of a variety of health problems. ... The potential toxicity of the hydroalcoholic extract of C. campestris leaves on Drosophila melanogaster ... were analysed in this study. ... Our data show important toxicological effects of C. campestris leading to increased mortality and impaired locomotor performance accompanied by induction of cell stress markers in flies. The study draws attention to the indiscriminate use of plant extracts."