Gavilan HS, Kulikauskas RM, Gutmann DH, Fehon RG. In Vivo Functional Analysis of the Human NF2 Tumor Suppressor Gene in Drosophila. PLoS One. 2014 Mar 4;9(3):e90853. PMID: 24595234; PMCID: PMC3942481.
From the abstract: "... Interestingly, we found that a patient-derived missense allele, NF2L64P, appears to be temperature sensitive. ..."
Sunday, March 30, 2014
Thursday, March 20, 2014
Fly models, cancer and aneuploidy--a review
Milán M, Clemente-Ruiz M, Dekanty A, Muzzopappa M. Aneuploidy and tumorigenesis in Drosophila. Semin Cell Dev Biol. 2014 Mar 15. pii: S1084-9521(14)00042-1. PMID: 24641887.
Wednesday, March 5, 2014
Review--flies and study of colorectal cancer
Bell GP, Thompson BJ. Colorectal cancer progression: Lessons from Drosophila? Semin Cell Dev Biol. 2014 Feb 27. pii: S1084-9521(14)00019-6. PMID: 24583474.
Reveiw--model systems in the study of autism spectrum disorders
Doll CA, Broadie K. Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models. Front Cell Neurosci. 2014 Feb 7;8:30. eCollection 2014. Review. PMID: 24570656; PMCID: PMC3916725.
Autophagy and neurodenenerative disease
Bakhoum MF, Bakhoum CY, Ding Z, Carlton SM, Campbell GA, Jackson GR. Evidence for autophagic gridlock in aging and neurodegeneration. Transl Res. 2014 Feb 3. pii: S1931-5244(14)00048-6. PMID: 24561013.
Flies used for signal pathway analysis in cancer-related study
Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest. 2013 Nov 1;123(11):4681-94. PubMed PMID: 24216479; PubMed Central PMCID: PMC3809775.
Monday, March 3, 2014
Fly cell study identifies conserved host cell factors related to West Nile Virus infection
Yasunaga A, Hanna SL, Li J, Cho H, Rose PP, Spiridigliozzi A, Gold B, Diamond MS, Cherry S. Genome-Wide RNAi Screen Identifies Broadly-Acting Host Factors That Inhibit Arbovirus Infection. PLoS Pathog. 2014 Feb 13;10(2):e1003914. PMID: 24550726; PMCID: PMC3923753.
From the abstract: "Investigation of two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1, in the Tip60 complex, demonstrated they contributed to antiviral defense at the organismal level in adult flies, in mosquito cells, and in mammalian cells. These data suggest the existence of broadly acting and functionally conserved antiviral genes and pathways that restrict virus infections in evolutionarily divergent hosts."
From the abstract: "Investigation of two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1, in the Tip60 complex, demonstrated they contributed to antiviral defense at the organismal level in adult flies, in mosquito cells, and in mammalian cells. These data suggest the existence of broadly acting and functionally conserved antiviral genes and pathways that restrict virus infections in evolutionarily divergent hosts."
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