Cagan R. Bench to bedside with fruit flies: an interview with Ross Cagan. Dis Model Mech. 2013 May;6(3):567-9. doi: 10.1242/dmm.012443. PMID: 23616076; PMCID: PMC3634641.
Cagan RL, Justice MJ, Tidmarsh GF. Bridging the gap between basic and applied biology: towards preclinical translation. Dis Model Mech. 2013 May;6(3):559-61.doi: 10.1242/dmm.012450. PMID: 23616075; PMCID: PMC3634639.
Thursday, October 31, 2013
Production and testing of a nanocomposite drug using fly models of Parkinson's Disease. Recent report.
Siddique YH, Khan W, Singh BR, Naqvi AH. Synthesis of alginate-curcumin nanocomposite and its protective role in transgenic Drosophila model of Parkinson's disease. ISRN Pharmacol. 2013 Sep 19;2013:794582. PMID: 24171120.
Tuesday, October 29, 2013
New fly model: Autism spectrum disorders. Recent report.
Hahn N, Geurten B, Gurvich A, Piepenbrock D, Kästner A, Zanini D, Xing G, Xie W, Göpfert MC, Ehrenreich H, Heinrich R. Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour. Behav Brain Res. 2013 Sep 1;252:450-7. PMID: 23792025.
From the abstract: "... Drosophila can thus be used to study the contribution of Neuroligins to synaptic function, social interactions and their implication in ASDs. "
From the abstract: "... Drosophila can thus be used to study the contribution of Neuroligins to synaptic function, social interactions and their implication in ASDs. "
Interplay between diet and cancer. Recent report
Hirabayashi S, Baranski TJ, Cagan RL. Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell. 2013 Aug 1;154(3):664-75. PMID: 23911328; PMCID: PMC3800019.
Flies & booze. Recent review.
Devineni AV, Heberlein U. The evolution of Drosophila melanogaster as a model for alcohol research. Annu Rev Neurosci. 2013 Jul 8;36:121-38. PMID: 23642133.
From the abstract: "... we describe the ecological relationship between flies and ethanol, the effects of ethanol on fly development and behavior, the use of flies as a model for alcohol addiction, and the interaction between ethanol and social behavior. We discuss ... their utility to help decipher the mechanisms underlying the diverse effects of ethanol, including those that mediate ethanol dependence and addiction in humans."
From the abstract: "... we describe the ecological relationship between flies and ethanol, the effects of ethanol on fly development and behavior, the use of flies as a model for alcohol addiction, and the interaction between ethanol and social behavior. We discuss ... their utility to help decipher the mechanisms underlying the diverse effects of ethanol, including those that mediate ethanol dependence and addiction in humans."
Flies & frontotemporal dementia (FTD3). New study implicates Notch signaling. Recent report.
Cheruiyot A, Lee JA, Gao FB, Ahmad ST. Expression of mutant CHMP2B, an ESCRT-III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila. FASEB J. 2013 Oct 24. PMID: 24158394.
Fly study sheds light on Pink1/Parkin pathway. Recent report relevant to Parkinson's Disease.
de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis. 2013 Oct 24;4:e873. PMID: 24157867.
From the abstract: We conclude that Ref(2)P [the fly ortholog of mammalian sequestrome-1 (p62/SQSTM1)] is a crucial downstream effector of a pathway involving Pink1 and Parkin and is responsible for the maintenance of a viable pool of cellular mitochondria by promoting their aggregation and autophagic clearance.
From the abstract: We conclude that Ref(2)P [the fly ortholog of mammalian sequestrome-1 (p62/SQSTM1)] is a crucial downstream effector of a pathway involving Pink1 and Parkin and is responsible for the maintenance of a viable pool of cellular mitochondria by promoting their aggregation and autophagic clearance.
Subscribe to:
Posts (Atom)