Fly study with relevance to DiGeorge syndrome

Luhur A, Chawla G, Wu YC, Li J, Sokol NS. Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1421-6. PMID: 24474768.

Ret and mitochondria in a fly Parkinson's Disease model.

Klein P, Müller-Rischart AK, Motori E, Schönbauer C, Schnorrer F, Winklhofer KF, Klein R. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J. 2014 Jan 28. PMID: 24473149.

Endonuclease-G in neurodegenerative disease. Report includes fly studies.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013 Nov 27;32(23):3041-54. PMID: 24129513; PMCID: PMC3844953.

In the above study, results from assays in yeast, C. elegans and Drosophila are combined to help uncover mechanisms underlying cytotoxicity associated with alpha-synuclein.

A comment on this "landmark" study appears in the same journal: Hogg MC and Prehn JH. Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location? EMBO J. 2013 Nov 27;32(23):3014-6. PMID: 24162725; PMCID: PMC3844957.

Fragile X model and GABAergic dysfunction

Gatto CL, Pereira D, Broadie K. GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model. Neurobiol Dis. 2014 Jan 12. pii: S0969-9961(14)00015-1. PMID: 24423648.

Review: Modeling obesity in flies.

Trinh I, Boulianne GL. Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda). 2013 Mar;28(2):117-24. PMID: 23455770.

Fly as a model for study of head trauma

Katzenberger RJ, Loewen CA, Wassarman DR, Petersen AJ, Ganetzky B, Wassarman DA. A Drosophila model of closed head traumatic brain injury. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4152-9. doi: 10.1073/pnas.1316895110. PMID: 24127584; PMCID: PMC3816429.

Fly study related to SMA

Borg R, Cauchi RJ. The gemin associates of survival motor neuron are required for motor function in Drosophila. PLoS One. 2013 Dec 31;8(12):e83878. PMID: 24391840; PMCID: PMC3877121.