Wednesday, January 29, 2014

Endonuclease-G in neurodegenerative disease. Report includes fly studies.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013 Nov 27;32(23):3041-54. PMID: 24129513; PMCID: PMC3844953.

In the above study, results from assays in yeast, C. elegans and Drosophila are combined to help uncover mechanisms underlying cytotoxicity associated with alpha-synuclein.

A comment on this "landmark" study appears in the same journal: Hogg MC and Prehn JH. Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location? EMBO J. 2013 Nov 27;32(23):3014-6. PMID: 24162725; PMCID: PMC3844957.

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