Tuesday, January 28, 2014

Catching up--they fly in neurodegenerative disease studies (including AD, PD, HD and ALS, plus retinal degeneration)

Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci. 2014 Jan 26. PMID: 24464041.

Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi S, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Carter RL, Westerberg G, Marsh JL. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014 Jan 16. PMID: 24436303.

Povellato G, Tuxworth RI, Hanger DP, Tear G. Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β. Biol Open. 2014 Jan 15;3(1):1-11. PMID: 24429107; PMCID: PMC3892155.

Zhu JY, Vereshchagina N, Sreekumar V, Burbulla LF, Costa AC, Daub KJ, Woitalla D, Martins LM, Krüger R, Rasse TM. Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson's Disease Model. PLoS One. 2013 Dec 30;8(12):e83714. PMID: 24386261; PMCID: PMC3875477.

Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB. Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS. J Neurosci. 2013 Dec 11;33(50):19590-8. PMID: 24336723; PMCID: PMC3858628.

Favrin G, Bean DM, Bilsland E, Boyer H, Fischer BE, Russell S, Crowther DC,Baylis HA, Oliver SG, Giannakou ME. Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Sci Rep. 2013 Dec 16;3:3512. PMID: 24336499; PMCID: PMC3863820.

Kim HJ, Raphael AR, Ladow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet. 2013 Dec 15. PMID: 24336168.

Sanhueza M, Zechini L, Gillespie T, Pennetta G. Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles. Biol Open. 2014 Jan 15;3(1):59-71. PMID: 24326187; PMCID: PMC3892161.

Singh MD, Raj K, Sarkar S. Drosophila Myc, a novel modifier suppresses the poly(Q) toxicity by modulating the level of CREB binding protein and histone acetylation. Neurobiol Dis. 2014 Mar;63:48-61. PMID: 24291519.

Moran MT, Tare M, Kango-Singh M, Singh A. Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration. PLoS One. 2013 Nov 25;8(11):e80829. doi: PMID: 24282556; PMCID: PMC3840013.

Prüßing K, Voigt A, Schulz JB. Drosophila melanogaster as a model organism for Alzheimer's disease. Mol Neurodegener. 2013 Nov 22;8:35. PMID: 24267573.

Steffensmeier AM, Tare M, Puli OR, Modi R, Nainaparampil J, Kango-Singh M, Singh A. Novel neuroprotective function of apical-basal polarity gene crumbs in amyloid beta 42 (aβ42) mediated neurodegeneration. PLoS One. 2013 Nov 18;8(11):e78717. PMID: 24260128; PMCID: PMC3832507.

Riemensperger T, Issa AR, Pech U, Coulom H, Nguyễn MV, Cassar M, Jacquet M, Fiala A, Birman S. A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 2013 Nov 27;5(4):952-60. PMID: 24239353.

Shieh BH. Molecular genetics of retinal degeneration: A Drosophila perspective. Fly (Austin). 2011 Oct-Dec;5(4):356-68. PMID: 21897116; PMCID: PMC3266078.

Hindle S, Afsari F, Stark M, Middleton CA, Evans GJ, Sweeney ST, Elliott CJ. Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy. Hum Mol Genet. 2013 Jun 1;22(11):2129-40. PMID: 23396536; PMCID: PMC3652415.

Hindle SJ, Elliott CJ. Spread of neuronal degeneration in a dopaminergic, Lrrk-G2019S model of Parkinson disease. Autophagy. 2013 Jun 1;9(6):936-8. PMID: 23529190; PMCID: PMC3672307.

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