Thursday, October 27, 2016

Do p53 mutations result in 'transposon-opathies'?

The interesting argument regarding p53, transposons, and cancer that is presented in this review draws in part from studies done in flies.

Wylie A, Jones AE, Abrams JM. p53 in the game of transposons. Bioessays. 2016 Nov;38(11):1111-1116. PMID: 27644006.

From the abstract: "Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. ..."
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  1. Stephanie MohrDecember 15, 2016 at 12:08 PM

    See also this research report from the same lab group:

    Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM. p53 genes function to restrain mobile elements. Genes Dev. 2016 Jan 1;30(1):64-77. PMID: 26701264; PMCID: PMC4701979.

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