Tuesday, July 31, 2012

Rab GTPase Gal4 Kit. Breaking Report.

The Gal4 expression 'kit' reported in this paper could be useful not only for studying Rab GTPases but also for Gal4-UAS mediated stage- or tissue-specific expression of other genes or reagents.

Jin EJ, Chan CC, Agi E, Cherry S, Hanacik E, Buszczak M, Hiesinger PR. Similarities of Drosophila rab GTPases Based on Expression Profiling: Completion and Analysis of the rab-Gal4 Kit. PLoS One. 2012;7(7):e40912. Epub 2012 Jul 23. PubMed PMID: 22844416.

According to the introduction of the paper, Rab GTPases or related factors have been implicated in at least the following: Griscelli Syndrome and Hermansky-Pudlak Syndrome, both of which are associated with albinism, as well as Charcot-Marie-Tooth Type 2B Disease, Warburg Micro Syndrome (also known by the abbreviation WARBM and as Warburg Sjo Fledelius Syndrome or simply Micro Syndrome), and X-linked mental retardation.

Related resource: UAS-Rab fly stocks at the BDSC. As described in Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP. Thirty-one flavors of Drosophila rab proteins. Genetics. 2007 Jun;176(2):1307-22. Epub 2007 Apr 3. PubMed PMID: 17409086; PubMed Central PMCID: PMC1894592.

No comments:

Post a Comment