Disease-associated mutations in Actin. New fly models. Recent report.

These authors report introducing six different mutant forms of actin associated with myopathies in humans into the fly indirect flight muscle, as well as characterization of the resulting phenotypes.

Sevdali M, Kumar V, Peckham M, Sparrow J. Human congenital myopathy actin mutants cause myopathy and alter Z-disc structure in Drosophila flight muscle. Neuromuscul Disord. 2013 Jan 4. doi:pii: S0960-8966(12)00698-0. 10.1016/j.nmd.2012.11.013. PMID: 23294764.