Wednesday, May 15, 2013

Sneak Preview: TRiP VAL20 in vivo RNAi fly stocks corresponding to highest-confidence fly disease gene orthologs

The DRSC/TRiP has launched a new web page that lists highest confidence fly orthologs of disease genes (DIOPT scores of 8, 9 or 10 at the time of analysis). This list is limited to human genes associated with disease at the NCBI Online Mendelian Inheritance in Man database (DIOPT-DIST search results will also report associations based on GWAS data).

The page lets you see if there are TRiP VALIUM20 fly stocks for these genes at the Bloomington Drosophila Stock Center. With links to details about the fly genes, human genes, etc. All of the genes on this list have been nominated and are in production for VAL20 TRiP fly stocks.

This resource should help you look at the reduction-of-function RNAi knockdown phenotypes of disease gene orthologs to develop new disease models or otherwise study gene function.

Expert tip:  To view the specific disease or diseases associated with a gene, click the DIOPT score. If you want to then expand the gene candidates list, you can use DIOPT-DIST to search for more genes that match the same disease term or use DIOPT to search for more orthologs of the human gene.

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