Tuesday, April 23, 2013

Classic Galactosemia (aka Type I Galactosemia) and long-term outcomes. Characterization of a fly model. Recent report.

Ryan EL, DuBoff B, Feany MB, Fridovich-Keil JL. Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia. Dis Model Mech. 2012 Nov;5(6):796-803. doi: 10.1242/dmm.009050. PMID: 22736462; Now freely available at PMCID: PMC3484862.

From the abstract:  "... our results confirm that, like human patients, GALT-null Drosophila experience significant long-term complications that occur independently of galactose exposure, and serve as a proof of principle demonstrating utility of the GALT-null Drosophila model as a tool for exploring genetic and environmental modifiers of long-term outcome in GALT deficiency."

See this post for comments from Annette Parks regarding galactosemia model fly stocks at BDSC.

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