den Hoed et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013 Jun;45(6):621-31. PMID: 23583979; PMCID: PMC3696959.
From the abstract: "Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. ... Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets."
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